Fig. 10

SeNPs ameliorate the psoriatic like skin disease by suppressing keratinocyte hyperproliferation and inflammation. A schematic diagram depicts the mechanism of SeNPs in psoriatic like skin disease. IMQ activates the TLR-7 and Th17, which results in epidermal hyperplasia and keratinocyte hyperproliferation. Whereas, EGF induces the Akt/mTOR/MAPKs signaling and further enhance the cell proliferation and inflammation. IMQ and EGF induced epidermal proliferation and inflammation is prevented by SeNPs by different canonical pathways