Fig. 7

SeNPS inhibit the pro-inflammatory cytokines by suppressing MAPK signaling. The levels of crucial T-cell mediated inflammatory cytokine levels were measured by ELISA. SeNPs treatment ameliorated the levels of these cytokines a IL-1β b IL-6 c IL-17 d IL-22 e TGF-β, induced by IMQ application and the efficacy was compared with the standard drug TAC. The phosphorylation of p38, p44/42, and JNK was determined in both (f–i) HaCaT cells as well as (j–m) BALB/C mice. Data represents Mean ± SD (in vitro n = 3; in vivo n = 5). **p < 0.01, ***p < 0.001, and ****p < 0.0001 are significantly different from the normal control group; ^p < 0.05, ^^p < 0.01, ^^^p < 0.001, and ^^^^p < 0.0001 are significantly different from the EGF and IMQ groups