Fig. 3

PLGA NPs are enriched at plaque sites (red) and co-localize with inflammatory cells (yellow). The experimental animals were fed with HFD for 12 weeks, then DiI@PLGA (2 mg/mL, 200 µL) was injected through the tail vein and DiI@PLGA were detected in arterial plaque 24 h after injection into the blood stream. CLSM images of the PLGA NPs co-localized with a CD68 positive cells and b CD11b positive cells (white arrow heads)