Fig. 10
From: Construction of nanomaterials as contrast agents or probes for glioma imaging
(Reprint with permission [198]. Copyright 2017, Wiley–VCH)
a Schematic diagram of the synthesis of RGD-Au–Mn DENPs. b Illustration of the MR/CT imaging function of RGD-Au–Mn DENPs. Reprint with permission [195]. Copyright 2019, Royal Society of Chemistry. c (i) The cleavage of the PEG coating in physiological acidity triggers aggregation between Au–AZ and Au–AK via “click” cycloaddition reactions. (ii) Due to the LPR1-mediated, bidirectional, BBB-traversing strategy, while the bulky AuNS aggregates are continuously trapped in tumor acidic interstitium, the intact nanoprobes in the normal brain tissue can be transported back into the bloodstream, which increases the sensitivity for the brain-tumor margins. d (i) Cartoons illustrating the procedure of Raman-spectroscopy-guided glioma resection. (ii) Photographs of the excised mouse brain bearing U87MG glioma xenografts and Raman spectra at the tumor site during the image-guided tumor resection