Fig. 2
From: Construction of nanomaterials as contrast agents or probes for glioma imaging
(Reprint with permission [82]. Copyright 2015, Royal Society of Chemistry)
a The synthesis route of TMP. b TMP nanoparticles crossing BBB through binding to transferrin receptors over-expressed on endothelial cells. c TMP nanoparticles wielding the function as both MR contrast agents and sono-sensitizers after surmounting BBB to achieve precise theranostics of glioblastoma. Reprint with permission [49]. Copyright 2020, WILEY–VCH. d Scheme of the GrB-SPIONs and the mechanism of action. Reprint with permission [60]. Copyright 2020, WILEY–VCH. e Schematic illustration of Fe3O4/MnO–Cy5.5–CTX NPs