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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Construction of nanomaterials as contrast agents or probes for glioma imaging

Fig. 8

(Reprint with permission [170]. Copyright 2020, Wiley–VCH)

a Representative small-animal Nano SPECT/CT MIP images and brain slice images (including transverse, coronal, and sagittal sections) of 99mTc-HisoDGR in an orthotopic U87MG glioma tumor model obtained at 0.5 h p.i. Arrows and crosshairs indicate tumor location. For all the SPECT images, the bladder was excluded during imaging reconstruction. (P represents a posterior view; R represents the right lateral view.) Reprint with permission [163]. Copyright 2016, American Chemical Society. b (i) Representative maximum intensity projection image of 99mTc-3PisoDGR2 at 1 h p.i. with the tumor size > 50 mm3. (ii) Representative sectional images of 99mTc-3PisoDGR2 at 1 h p.i. with the tumor size < 2 mm3. Reprint with permission [161]. Copyright 2019, American Chemical Society. c Structures of the terpolymer and PS 80, and a schematic diagram of the self-assembly of PMAAPS 80-g-St terpolymer into nanoparticles upon conjugation of the fluorescent moieties, chelation with Gd3+, and complexation with doxorubicin. Reprint with permission [168]. Copyright 2014, American Chemical Society. d Schematic illustration of the molecular probe (iRGD-ILD) crossing BBB via αvβ3 integrin-receptor-mediated transcytosis to enable bimodal MR/fluorescence imaging-guided photothermal/photodynamic therapy of intracranial glioblastoma

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