Fig. 9
From: Construction of nanomaterials as contrast agents or probes for glioma imaging
(Reprint with permission [177]. Copyright 2014, American Chemical Society)
a Steps for preparation of Cy5.5-Lf-MPNA nanogels. b Illustration of the functioning mechanisms of Cy5.5-Lf-MPNA nanogels. Reprint with permission [172]. Copyright 2014, Elsevier. c Schematic illustration of the principle of intranasal polyGION-miRNAs delivery and its theranostic imaging and therapeutic effect in GBM in vivo. Reprint with permission [171]. Copyright 2019, Elsevier. d (i) Design of the dual-targeting ANG/PEG-UCNPs. (ii) Schematic diagram of the ANG/PEG-UCNPs as the dual targeting system to cross the BBB and target the glioblastoma via LRP mediated endocytosis, enabling MR and UCL imaging of intracranial glioblastoma