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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: A heparin–rosuvastatin-loaded P(LLA-CL) nanofiber-covered stent inhibits inflammatory smooth-muscle cell viability to reduce in-stent stenosis and thrombosis

Fig. 8

Effects of PDGF-BB- and rosuvastatin-treated SMCs on phenotype markers and inflammatory cytokines. a Fold changes in mRNA levels of α-SMA, SM22-α, OPN, and inflammatory cytokines. Data represent the mean ± SD (n = 3/group). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. b Western blot analysis of SM22-α, OPN, and MMP-9 levels. Data represent the mean ± SD (n = 3/group). *p < 0.05, **p < 0.01. c Inflammatory cytokines analyzed using MILLIPLEX MAP rat cytokine/chemokine factor panel. Data represent the mean ± SD (n = 3/group). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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