a Synthesis of pB-DOX. b Schematic illustration of Lipo/pB-DOX/ICG combined PDT with ROS-responsive chemotherapy to synergistically treat cancer cells. (1) The ICG-generated ROS would exert PDT by inducing cell necrosis or apoptosis and selectively cleave the boronate moiety of pB-DOX under 808 nm laser irradiation, triggering DOX release for chemotherapy. (2) ICG could generate localized hyperthermia by absorbing NIR for PTT. (3) Lipo/pB-DOX/ICG offers FI and PAI approaches for visualizing its dynamic distribution within the whole body. (4) With low endogenous ROS levels and without light irradiation, normal tissues could be free from damage