Fig. 5

A In vivo (1 h vs 24 h post-injection) and ex vivo (24 h post-injection) fluorescent imaging of MDA-MB-231 tumor-bearing mice treated with free Ce6 and PTFCG@MH. B The quantified fluorescence intensity in major organs and tumor tissue at 24 h post injection. C Kinetics of tumor growth inhibition with various treatments. D Tumor mass and tumor images (inset) of the extracted tumor tissues after different treatments. E H&E staining and F HIF-1α immunofluorescence staining of the tumor tissues with different treatments. G The quantified HIF-1α level after different treatments. **P < 0.01, ***P < 0.001. In each panel, G1: PBS; G2: Ce6 + Laser; G3: PTFCG + Laser; G4: PTFCG@MH; G5: PTFCG@MH + Laser