Fig. 8

PGZ-Exos accelerated diabetic wound healing. A Representative images of full thickness defects in diabetic rats receiving treatment with PBS (Con), exosomes and PGZ-Exo at days 0, 3, 7, 10, and 14 day postoperatively. B Wound healing closure rates was calculated among the different groups using the ImageJ software. C, D Blood perfusion of wounds was assessed with Doppler detection. The results of blood perfusion is presented as the ratio of wound area (ROI-1) to area surrounding the wound (ROI-2). E, F HE staining and quantification of wound length at day 14. Scale bar: 2.5 mm. G Masson’s trichrome staining at day 14. Scale bar: 50 μm