Fig. 1

S1PR1 overexpression in BRCA causes poor survival and is positively correlated with STAT3 and VEGFA. a–e TCGA database suggest the correlation between patient survival and S1PR1 expression in every stage of breast cancer. f Oncomine database analysis of S1PR1 expression in breast cancer and adjacent normal tissue. Mean ± SEM, *P < 0.05. g–i Oncomine database analysis of VEGFA expression in breast cancer and adjacent normal tissue. ICBA is intraductal cribriform breast adenocarcinoma, DBC is ductal breast carcinoma, IDBC is invasive ductal breast carcinoma, and LBC is lobular breast carcinoma. Mean ± SEM, **P < 0.01, ***P < 0.001. j, k TIMER database analysis of the relationship between S1PR1 and STAT3 or STAT3 and VEGFA. “Cor” represents the correlation value, and p is the p value, with values less than 0.05 being considered meaningful. BRCA is breast invasive carcinoma. l String database suggest the connection of S1PR1 and STAT3 and VEGFA in breast cancer, p value less than 0.05 is considered meaningful