Fig. 8

BAF312@cRGD-CaP-NPs inhibit tumor growth and angiogenesis in vivo via downregulating the expression of the S1PR1/P-STAT3/VEGFA. a Immunofluorescence assay analysis of TUNEL in the tumors. Scale bar: 50 µm. b IHC analysis of Ki67 expression in the tumors. Scale bar: 50 µm. c Immunofluorescence assay analysis of CD31 in the tumors. Scale bar: 50 µm. d The statistical results of TUNEL positivity in MDA-MB-231 tumors. Mean ± SEM, n = 3, **P < 0.01, ***P < 0.001. e The statistical results of Ki67 positivity in MDA-MB-231 tumors. Mean ± SEM, n = 3, **P < 0.01, ***P < 0.001. f The statistical results of CD31 for MDA-MB-231 tumors. Mean ± SEM, n = 3, *P < 0.05, **P < 0.01, ***P < 0.001. g The proteins expression of S1PR1, P-STAT3, VEGFA, and Bax were determined by IHC in tumors of which collected at the end point. Scale bar: 50 µm