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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway

Fig. 1

The benefits of melatonin was correlated with gut microbiota. A Representative view of calvarium in each group via Micro-CT 3D reconstruction. B–D Quantification of bone erosion parameters (BV/TV) bone volume to tissue volume ratio, (BMD) bone mineral density, and total porosity. n = 6. E Percentage of osteoclasts surface per bone surface (OCs/BS, %). n = 5. F H&E and G TRAP staining of calvarium slices from each group. H Principle coordinate analysis (PCoA) plot from sham (PBS), Ti (Ti exposure), and MT (Ti exposure and melatonin treatment) groups based on the Bray Curits distance. n = 6. I Relative abundance of SCFA producing microbes in mice feces. n = 6. Results are expressed as mean ± SEM (One-way ANOVA[post hoc:SNK] *p < 0.05, **P < 0.01, ***p < 0.001)

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