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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway

Fig. 3

The anti-osteolysis effect of melatonin could be transmitted by fecal microbiota transplantation. A Representative view of calvarium in each group via Micro-CT 3D reconstruction. B Relative abundance of SCFA producing microbes in fecal samples n = 6. C Three major SCFA concentration in fecal samples. n = 6. D Butyrate synthesis related enzymes. n = 6 in each group. Results are expressed as mean ± SEM (Unpaired t-tests * p < 0.05, ** p < 0.01). E–G Quantification of bone erosion parameters (BV/TV) bone volume to tissue volume ratio, (BMD) bone mineral density, and total porosity. n = 6. Results are expressed as mean ± SEM (One-way ANOVA[post hoc:SNK] ***p < 0.001)

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