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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver

Fig. 4

Schematic representation of the prolonged (120 h) single, bolus ENM exposure regime and the fractionated, repeated ENM exposure regime assessed using 3D HepG2 spheroids and key biochemical endpoint analysis techniques selected. A Colourmetric based assay for albumin quantification. B CellSens X63 image displaying binucleate formation following the cytokinesis-block micronucleus (CBMN) assay with the presence of a micronucleus. C (Pro)-inflammatory ELISAs for Interleukin 8 (IL-8), Interleukin-6 (IL-6) and Tumor Necrosis Factor Alpha (TNF-α). Created with Biorender.com

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Journal of Nanobiotechnology

ISSN: 1477-3155

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