Fig. 1
From: Intratumoral administration of astatine-211-labeled gold nanoparticle for alpha therapy
C6 glioma cells (A, B, C, D) and PANC-1 cells (E, F, G, H) were cultured for 24 h with saline as a control, 1 MBq/mL of 211At, or 211At-AuNP-S-mPEG labeled with 0 to 1 MBq/mL of radioactivity and a diameter of 5 nm (A, E), 13 nm (B, F), 30 nm (C, G) or 120 nm (D, H). For the evaluation of cell viability, CCK8 Kit was used. WTS-8 solution was added and the cells were cultured for 2 h. Viability was calculated by measuring the absorbance as shown in the formula below: \(\mathrm{Viability}\left(\mathrm{\%}\right)=\frac{T-{T}_{0}}{C-{C}_{0}}\), where T is absorbance of the test cells, T0 is background of the test cells, C is the absorbance of the control cells, and C0 is the background of the control cells. The mass concentrations of AuNP-S-mPEG labeled with 1 MBq/mL 211At in (A, B, C, D) were almost the same level as those in (A, C, E, G) in Fig. 2, respectively (see Additional file 1: Table S3).