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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: MiR-144-5p, an exosomal miRNA from bone marrow-derived macrophage in type 2 diabetes, impairs bone fracture healing via targeting Smad1

Fig. 3

dBMDM-exos hinder BMSCs osteogenesis differentiation in vitro. a–c The protein and mRNA levels of some osteogenic genes in BMSCs treated with PBS, nBMDM-exos or dBMDM-exos were determined by Western blotting and RT-qPCR analyses, respectively. d The proportion of mineralization in treated BMSCs was shown by Alizarin red staining and ALP staining assays. e, f The Alizarin red and ALP staining were quantitatively determined. Data are presented as the mean ± SD (n = 3 per group), *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.001

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