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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: MiR-144-5p, an exosomal miRNA from bone marrow-derived macrophage in type 2 diabetes, impairs bone fracture healing via targeting Smad1

Fig. 4

dBMDM-exos impair femoral fractur healing in vivo. a–c The osteogenic genes at the mRNA and protein levels in fractures region locally injected with PBS, nBMDM-exos or dBMDM-exos for 21 days were measured via qRT-PCR and western blotting. d Representative X-ray images of femurs on 14 and 21 days after surgery from different treated groups. e Representative 3D micro-CT images of femurs among different treatment groups on day 21 after surgery. f The BV/TV data on 21 days after surgery were quantitatively analyzed based on micro-CT results. g H&E, safranin O-fast green staining and Masson of the femurs on day 21 after surgery. Data are presented as the mean ± SD. n = 5 rats/group, *p < 0.05, **p < 0.01, ***p < 0.00,****p < 0.001

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