Fig. 5

MiR-144-5p was sharply increased in dBMDM-exos and it can be transferred to BMSCs via exosomes. a The heat map showed that differently expressed miRNAs(|logFC|>1, P < 0.05. b Volcano plot of miRNAs expressed differently in dBMDM-exos or nBMDM-exos. c The schematic diagram of microRNA screening and selection. d qRT-PCR analyses confirmed that, among the top 5 most upregulated miRNAs in the dBMDM-exos, miR-144-5p was increased to the greatest degree. e Comparison of miR-144-5p levels between nBMDMs and dBMDMs, as determined with qRT-PCR assay. f The miR-144-5p expression levels among groups following BMSCs treated with PBS, nBMDM-exos or dBMDM-exos. Data are presented as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001