Fig. 1

Comparison of WRAP and C6M1 cell-penetrating peptides. A Table summarizing the WRAP and C6M1 peptide sequences and their characteristics. B Graphical representation of the relative Luc activity (%) and relative cytotoxicity (LDH quantification, %) after transfection with CPP:siRNA complexes on U87 cells. Conditions: CPP:siRNA (R = 20) using a siRNA concentration of 10 nM and a peptide concentration of 200 nM. Abbreviations: siLuc = firefly luciferase siRNA, siSCR = scrambled version of the siLuc, N.T. = non-treated cells, Ctrl = Controls. Data represent mean ± SD, with n = 2 independent experiments in triplicate