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Table 1 Characterization of the WRAP peptides and their analogues used in this study

From: WRAP-based nanoparticles for siRNA delivery: a SAR study and a comparison with lipid-based transfection reagents

  1. Represented in the table are the primary sequences (red = amino acids implicated in the helix according to PEPstrMOD prediction), the number of amino acids (AA), the number of charges, the mean size [Z-average, nm] and the polydispersity index (PDI), the stability of the PBNs after a 4 day-period at 4°C, the helix signal in CD measurements, the number of amino acids implemented in the helix (AA in helix), and the calculated number of helix turn (number of amino acids in the helix divided by 3.6 as predicted by PEPStrMOD calculation), the luciferase silencing activity and the level of silencing in percentage at the dose of 10 nM siRNA