Table 1 Main pharmacokinetic parameters of Res in each group (n = 5, mean ± SD)
From: pH-sensitive dual drug loaded janus nanoparticles by oral delivery for multimodal analgesia
Parameters | Unit | Parameter value | |||
|---|---|---|---|---|---|
Free Res | Res-JNP | αCT-JNP + Res-JNP | αCT/Res-JNP | ||
t1/2α | 1/h | 0.19 ± 0.02 | 1.25 ± 0.02** | 1.11 ± 0.36** | 1.47 ± 0.22** |
t1/2β | h | 1.09 ± 0.07 | 4.65 ± 0.94** | 4.76 ± 1.08** | 4.35 ± 1.37** |
Cmax | ng/ml | 92.06 ± 8.00 | 215.53 ± 21.64** | 249.98 ± 15.93** | 204.52 ± 20.53** |
Tmax | h | 0.17 | 0.75 | 0.75 | 0.75 |
AUCt | ng/ml*h | 84.64 ± 3.80 | 750.91 ± 167.35** | 606.16 ± 54.78** | 677.96 ± 70.71** |
AUMCt | ng/ml*h^2 | 118.18 ± 19.08 | 2171.83 ± 296.19** | 1868.18 ± 177.18** | 1964.63 ± 217.18** |
MRTt | h | 1.56 ± 0.52 | 3.73 ± 1.25** | 4.26 ± 2.45* | 3.01 ± 1.77 |