Table 2 Main pharmacokinetic parameters of αCT in each group (n = 5, mean ± SD)
From: pH-sensitive dual drug loaded janus nanoparticles by oral delivery for multimodal analgesia
Parameters | Unit | Parameter value | |||
|---|---|---|---|---|---|
Free αCT | αCT-JNP | αCT-JNP + Res-JNP | αCT/Res-JNP | ||
t1/2α | 1/h | 0.17 ± 0.03 | 0.36 ± 0.02** | 0.34 ± 0.04** | 0.35 ± 0.03** |
t1/2β | h | 2.69 ± 0.36 | 5.61 ± 0.43** | 5.37 ± 0.31** | 5.40 ± 0.17** |
Cmax | ng/ml | 26.85 ± 3.00 | 68.97 ± 5.27** | 56.92 ± 10.91** | 62.50 ± 7.72** |
Tmax | h | 0.5 | 1.0 | 1.0 | 1.0 |
AUCt | ng/ml*h | 67.65 ± 17.91 | 168.17 ± 18.36** | 209.84 ± 28.92** | 230.71 ± 36.01** |
AUMCt | ng/ml*h^2 | 112.44 ± 12.97 | 655.91 ± 42.06** | 649.69 ± 115.07** | 758.61 ± 82.74** |
MRTt | h | 1.91 ± 0.02 | 1.91 ± 0.02** | 3.34 ± 0.05** | 3.38 ± 0.06** |