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Table 3 Absorption of perfusate in different intestinal segments (n = 3, mean ± SD)

From: pH-sensitive dual drug loaded janus nanoparticles by oral delivery for multimodal analgesia

Intestinal segments

Ka/ × 10–2 (min−1)

Peff/ × 10–3 (cm·min−1)

Ka/ × 10–2 (min−1)

Peff/ × 10–3 (cm·min−1)

Res

αCT/Res-JNP

Res

αCT/Res-JNP

αCT

αCT/Res-JNP

αCT

αCT/Res-JNP

Ileum

1.91 ± 0.66

2.16 ± 0.29

3.26 ± 1.26

3.72 ± 0.57

0.91 ± 0.03

2.52 ± 0.16∆∆

1.44 ± 0.05

4.45 ± 0.33∆∆

Jejunum

1.55 ± 0.26

1.77 ± 0.17

2.57 ± 0.46

2.96 ± 0.32

0.98 ± 0.05

2.07 ± 0.43

1.56 ± 0.10

3.55 ± 0.85

Duodenum

0.99 ± 0.11

1.54 ± 0.13**

1.58 ± 0.18

2.54 ± 0.23**

0.81 ± 0.11

1.52 ± 0.37

1.27 ± 0.19

2.51 ± 0.68

Colon

1.01 ± 0.26

1.62 ± 0.45

1.60 ± 0.44

2.66 ± 0.81

0.85 ± 0.14

1.53 ± 0.42

1.34 ± 0.23

2.53 ± 0.76

  1. Compared with free Res, ** p < 0.01;
  2. Compared with free αCT, p < 0.05, ∆∆ p < 0.01