From: pH-sensitive dual drug loaded janus nanoparticles by oral delivery for multimodal analgesia
Intestinal segments | Ka/ × 10–2 (min−1) | Peff/ × 10–3 (cm·min−1) | Ka/ × 10–2 (min−1) | Peff/ × 10–3 (cm·min−1) | ||||
---|---|---|---|---|---|---|---|---|
Res | αCT/Res-JNP | Res | αCT/Res-JNP | αCT | αCT/Res-JNP | αCT | αCT/Res-JNP | |
Ileum | 1.91 ± 0.66 | 2.16 ± 0.29 | 3.26 ± 1.26 | 3.72 ± 0.57 | 0.91 ± 0.03 | 2.52 ± 0.16∆∆ | 1.44 ± 0.05 | 4.45 ± 0.33∆∆ |
Jejunum | 1.55 ± 0.26 | 1.77 ± 0.17 | 2.57 ± 0.46 | 2.96 ± 0.32 | 0.98 ± 0.05 | 2.07 ± 0.43∆ | 1.56 ± 0.10 | 3.55 ± 0.85∆ |
Duodenum | 0.99 ± 0.11 | 1.54 ± 0.13** | 1.58 ± 0.18 | 2.54 ± 0.23** | 0.81 ± 0.11 | 1.52 ± 0.37∆ | 1.27 ± 0.19 | 2.51 ± 0.68∆ |
Colon | 1.01 ± 0.26 | 1.62 ± 0.45 | 1.60 ± 0.44 | 2.66 ± 0.81 | 0.85 ± 0.14 | 1.53 ± 0.42 | 1.34 ± 0.23 | 2.53 ± 0.76 |