Fig. 11
The effect of NPs on serum Ca, P, TRACP-5b, PINP, OC, and CTX1 at end of study (week 13, n = 9). *P < 0.05 versus Sham; #P < 0.05 versus PEG-PLGA-AL@E2 NPs; △P < 0.05 versus PEG-PLGA-AL@Fe3O4/E2 NPs. Treatment groups TG1: OVX, TG2: free E2, TG3: PLGA@E2 NPs, TG4: AL-PLGA@E2 NPs, TG5: PEG-PLGA@E2 NPs, TG6: PEG-PLGA-AL@E2 NPs, TG7: PEG-PLGA-AL@Fe3O4 NPs, TG8: PEG-PLGA-AL@Fe3O4/E2 NPs, TG9: PEG-PLGA-AL@Fe3O4/E2 NPs + MF