Fig. 7
Bone-targeted ability of NPs. In vivo fluorescence images (a) of SD rats 24 h after tail vein injection of DiR-labeled NPs. Ex vivo fluorescence images (b) of excised organs at 24 h post injection: heart (A), liver (B), spleen (C), lung (D), kidney (E), lumbar vertebra (F), femur, tibia and fibula (G). Ex vivo fluorescence images (c) of lumbar vertebra (F), femur, tibia and fibula (G). Fluorescence intensity quantification (d) of excised bone tissue. Data are mean ± standard deviation (n = 3). Treatment groups TG1: PLGA@DiR NPs, TG2: AL-PLGA@DiR NPs, TG3: PEG-PLGA@DiR NPs, TG4: PEG-PLGA-AL@DiR NPs, TG5: PEG-PLGA-AL@Fe3O4/DiR NPs