Fig. 6
Changes in the expression of apoptosis-associated proteins in A549 cells treated with PTX and IR780 co-loaded preparations. The “Control” (I), “PTX/IR780-HA&RBCm-LCNPs” (II), and “PTX/IR780-HA&RBCm-LCNPs + NIR” (III) groups refer to cells not treated with drugs, non-NIR treated nano-formulations, and NIR-treated nano-formulations, respectively. A the apoptosis-related proteins assayed through western blotting (n = 3); B western blotting bands. For the phototherapy group, cells were exposed to NIR at 808 nm (1 W/cm2) for 5 min 2 h post-drug administration. Bcl-2 B-cell lymphoma 2, Bax Bcl-2-associated X protein, COX-2 cyclooxygenase-2. ****p < 0.0001, ***p < 0.001, *p < 0.05