Fig. 7
Migration of A549 cells in vitro following treatment with PTX and IR780 co-loaded preparations. The “Control” (I), “PTX/IR780-HA&RBCm-LCNPs” (II), and “PTX/IR780-HA&RBCm-LCNPs + NIR” (III) refer to cells not treated with drugs, non-NIR treated nano-formulations, and NIR-treated nano-formulations, respectively. A Cell migration micrographs; B cell migration rates; C related proteins assayed by western blotting. The final PTX and IR780 concentrations were 2.5 µg/mL and 0.5 µg/mL, respectively (n = 3). For the phototherapy group, cells were exposed to NIR at 808 nm (1 W/cm2) for 5 min 2 h post-drug administration. MMP-2 matrix metalloproteinase 2; tissue inhibitor 2 of matrix metalloproteinase-2, TIMP-2. ****p < 0.0001, **p < 0.01, *p < 0.05