Fig. 3

Cell viability of differentiated human neuroblastoma cell line SH-SY5Y exposed to 20 µmol/L 6-OHDA neurotoxin and treated with differently charged PAMAM cores, PAMAM- and PEGylated PAMAM-based nanoparticles. The control (100% viability) are cells treated 7 h (part A) and 24 h (part B) with 20 µmol/L 6-OHDA only. The data represent means ± SD for 30 experiments. Data distribution was tested using Shapiro–Wilk test. To compare two analysed datasets the unpaired t-test was used. The analysis of variances between different time-points was performed using one-way ANOVA. *—p < 0.05, **—p < 0.01, ***—p < 0.001