Fig. 9

In vivo anti-tumor efficiency of different drug formulations in mice bearing 4T1 xenograft tumors. a Tumor growth curves and b relative body weight during treatment. Mice were injected via tail vein with PBS, free CDDP, TD, TD/CDDP, TP/CDDP or CTP/CDDP on days 6, 8, 10 and 12 after tumor inoculation. c Weight and d image of excised tumors at the end of the experiment (day 24 after tumor inoculation). e Immunohistochemical analysis including HIF-1α, MRP2, E-cadherin and N-cadherin of 4T1 xenograft tumors. Data are expressed as mean ± SD (n = 5), *p < 0.05, ***p < 0.001