Table 1 Cell penetrating peptides for CNS disease treatment

CAMP-hMT1A

CAMP

YGRKKRRQRRRLLRAALRKAAL

Eliminate ROS and restore mitochondrial activity

PD

[158]

TP10-DA

TP10

AGYLLGKINLKALAALAKKIL

Anti-parkinsonian activity (higher than that of l-DOPA)

PD

[97]

RAS-MAP

MAP

LALKLALKALKAALKLA

Reduces α-syn aggregation

PD

[98]

SynB1-B-Pc

SynB1

RGGRLSYSRRRFSTSTGR

Increased the brain uptake of benzylpenicillin

Encephalitis

[95]

Aβ1-6A2VTAT(D)

TAT

YGRKKRRQRRR

Inhibits Aβ aggregation and cerebral amyloid deposition

AD

[159]

eGFP-TAT

TAT

YGRKKRRQRRR

Increased the amount of M receptor with modulation of acetylcholinesterase in scopolamine-induced rats

AD

[160]

JNKI

TAT

TAT (48–57)

Block the c-Jun N-terminal kinase (JNK) pathway

Cerebral ischemia

[161]

ACPP-Cy5

R9

RRRRRRRRR

Examine gelatinase activity

Image in stroke model

[162]

PTD-HA-Bcl-xL

TAT

YGRKKRRQRRR

Inhibited staurosporininduced neuronal apoptosis

Stroke

[163]

Tat-NBD

TAT

YGRKKRRQRR

Anti-NF-κB strategy

Hypoxic-ischemic (HI) brain injury

[164]

TFL457

TAT

YGRKKRRQRR

Prevents receptor disappearance from the neuronal surface

Stroke

[165]

PTD-FNK

TAT

YGRKKRRQRRR

Generate the super

antiapoptotic factor

Stroke

[166]

TAT-Hsp70

TAT

RKKRRQRRR

Antiapoptotic

Cerebral ischemia

[167]

M1-RGD

M1

TFYGGRPKRNNFLRGIRSRGD

Treat glioma and triple-negative breast cancer brain metastases

Glioma

[104]

Vim-TBS.58–81-P10

Vim-TBS.58–81

Biot-GGAYVTRSSAVRLRSSVPGVRLLQ-CONH2

Inhibits cell proliferation

Glioma

[106]

gHoPe2-Dox

pVEC

LLIILRRRIRKQAHAHSK-NH₂

Antitumor efficacy

Glioma

[168]

c[DKP-RGD]-sC18

sC18

GLRKRLRKFRNKIKEK-NH₂

target tumor and antitumor efficacy

Glioma

[169]