Fig. 5
In vivo positron emission tomography (PET) images and assessment of passive tumor targeting efficiency of 64Cu-LAL. a Representative PET images of 4T1 breast cancer bearing mouse model (n = 3) at the different time points (0, 2, 12, and 24 h). White circles indicate tumor. Upper row: coronal, lower row: maximal intensity projection (MIP). b Radiochemical stability of 64Cu-LAL in PBS at 0, 2, and 24 h after radiolabeling. c Quantitative analysis of major organs (heart, liver, spleen, and muscle) and tumors from the PET images at each time point (n = 3, mean ± s.d.). d The circulation half-life from the time activity curve of blood pool. Tumor targeting efficiency comparison with non-targeted organ, e heart, f liver, g spleen, and h muscle (n = 3, mean ± s.d.)