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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Extracellular vesicles derived from CD73 modified human umbilical cord mesenchymal stem cells ameliorate inflammation after spinal cord injury

Fig. 5

CD73+hucMSC-EVs ameliorate SCI and decrease intracellular cAMP levels in mice. (A and B) In vivo biodistribution of DiR-labeled CD73+hucMSC-EVs. Mice are analyzed at 24 h after A subcutaneous injection of EVs around injured spinal cord and B intraperitoneal injection of EVs. C BMS scores at different time-point after spinal cord injury. D BBB scores at different time-point after spinal cord injury. E cAMP levels from cerebrospinal fluid at different time-point after spinal cord injury. F Histological images (H&E staing), G Nissl staining and (H) TUNEL staining of longitudinal sections of injured spinal cords on day 21

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