Fig. 2

Human skin xenograft preserves normal human skin architecture. a–c Human skin grafting onto immunocompromised nude mice with scale bar = 1 cm. d Human skin xenograft appears viable grossly and is adherent after 8 weeks of engraftment. H&E stains of e human skin xenograft after 8 weeks of engraftment and f partial-thickness human skin prior to skin grafting. The human skin xenograft preserves the key features of normal human skin including hair follicles (denoted by asterisk), rete ridges (denoted by arrowhead), and eccrine glands (denoted by hash). The epidermis (epi) is separated from the dermis using a yellow dotted line; dermis is composed of papillary dermis (pap der) and reticular dermis (ret der), and their interface is denoted by a blue dotted line. Scale bar = 500 µm low magnification; 100 µm for high-magnification insets