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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Accelerated complete human skin architecture restoration after wounding by nanogenerator-driven electrostimulation

Fig. 6

NG-ES facilitated restoration of normal tissue architecture. Representative H&E stained sections of wound region (denoted by black bracket) after (a, b) 4 and (c, d) 7 days with or without NG-ES treatment. Leading edge of the neo-epidermis is denoted by black arrows and entire basal epidermal layer is denoted by yellow dotted line. (c and inset) Day 7 of NG-ES treated wound demonstrating complete re-epithelialization (entire dotted yellow line) in wound region and reconstitution of normal architecture including hair follicle (denoted by asterisk) and rete ridges (denoted by arrowheads) also seen in low magnification. Scale bar = 500 µm low magnification; 100 µm for high-magnification insets. GT, granulation tissue; epi, epidermis; der, dermis. g, f Percentage of epithelialization with or without NG-ES treatment at 4 days (n = 3 per group) and 7 days (n = 4 per group) post-injury. *p < 0.05

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