Fig. 7

HPDA increased the pro-regenerative activity of RL-QN15 against oral ulcers in rat. A Representative images of oral ulcers on different postoperative days, showing effects of Vehicle (PBS), HPDA (0.1 mg/mL), RL-QN15 (1 nM), and HPDAlR groups. B Quantitative healing curves of ulcers treated with vehicle (PBS), HPDA, RL-QN15, and HPDAlR. Values were expressed as Mean ± SD (n = 10). Error bars represent SD. *P < 0.05, and ***P < 0.001 indicated statistically different from RL-QN15 group (Student t-test). C Representative images of histopathological changes in oral ulcers in vehicle (PBS), HPDA, RL-QN15, and HPDAlR groups on postoperative days 2 and 4. u, ulcerated oral epithelium. h, chronic hyperplastic epithelium. K, hyperkeratosis. Inflammatory cells were indicated by black arrows. Scale bar was shown by black line in bottom-right corner of images