Fig. 5

The ability of RL-QN15 against burn wound was obviously improved by the load of MPDA. A Representative images of scald wounds on days 0, 4, 8, and 12 post-injury in PBS, MPDA, RL-QN15, and MPDA + RL-QN15 groups. MPDA (0.2 mg/mL), RL-QN15 (1 nM), and nanocomposites of MPDA (0.2 mg/mL) + RL-QN15 (1 nM) were applied topically twice a day to skin wounds. B Quantitative curves of pro-healing activities of PBS, MPDA, RL-QN15, and nanocomposites of MPDA + RL-QN15. C Representative images of burns sections stained with H&E indicating histomorphological changes in skin wounds on days 8 and 12 post-injury in PBS, MPDA (0.2 mg/mL), RL-QN15 (1 nM), and nanocomposites of MPDA (0.2 mg/mL) + RL-QN15 (1 nM) groups. NE, neo-epidermal; GT, granulation tissue; ES, eschar; M, muscle. D, E Histological re-epithelialization of epidermis on days 8 and 12 post-injury. Data were presented as mean ± S.D. from 9 mice (n = 9). *P < 0.05, **P < 0.01, and ****P < 0.0001 indicated statistically differences between two groups