Fig. 5

Orthotopic SKHep1 HCC model response to nanocomposites with in vivo I.V. injection. a, b MRI T2-weighted imaging and transverse images showed the injection results with 100 μL of FePt@MMT in PBS (concentration of 10 mg/mL) into mice. c IVIS images show the results of tumors on different nanocomposites, including control, MIT, and FePt@MMT-MIT (The experimental mice were from the same group but arranged differently). The mice liver organs were detected with d visual diagrams and e IVIS analysis diagrams. Tumor growth assessment for different treatment groups between MFH or MIT treatment, n = 8 per group, including f tumor size evaluated from related IVIS images (*p < 0.05 compared with the control group). g Bodyweight continued changes of 5-week-old mice and h the survival curve of mice with different groups,i) and H&E staining result. Related images were visualized from 5× and 40× . (scale bar: 3 μm and 200 nm)