Fig. 2
Physicochemical characterization of nanocarriers. A N2 adsorption/desorption isotherms and B pore size distribution of SPION@MSNs and Au-NPs@DOX. C VSM curves of SPION@MSNs and PEG-Au-NPs@DOX. D The conjugation of EpCAM aptamer was verified by electrophoresis. E TGA analysis curves of (a) SPION@MSNs, (b) SPION@MSNs-NH2, (c) Au-NPs@DOX, (d) PEG-Au-NPs@DOX and (e) Apt-PEG-Au-NPs@DOX. F In vitro DOX release profile of Au-NPs@DOX at pH 7.4 and pH 5.4 (data presented as mean ± SD, n = 3). SPION Superparamagnetic iron oxide nanoparticle, MSN Mesoporous silica nanoparticle, NP nanoparticle, DOX Doxorubicin, VSM Vibration sample magnetometer, PEG Polyethylene glycol, Apt Aptamer, EpCAM Epithelial cell adhesion molecule, TGA Thermal gravimetric analysis