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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Improving anti-cancer drug delivery performance of magnetic mesoporous silica nanocarriers for more efficient colorectal cancer therapy

Fig. 7

In vivo possible side effects evaluation. A H&E staining of main organs (liver, kidney, spleen, heart, and lung) collected on day 15 after treatments. Local accumulation of inflammatory cells in the liver and kidney (black arrows) were noticed in free DOX treated group. Moreover, vacuolar degeneration of hepatocytes associated with sinusoidal dilatation and congestion (yellow arrows) were detected in that group. Scale bar: 200 μm. B Body weight changes of immunocompromised C57BL/6 mice bearing human HT-29 cells during various treatments (n = 5). SPION Superparamagnetic iron oxide nanoparticle, MSN Mesoporous silica nanoparticle, PEG Polyethylene glycol, NP nanoparticle, Apt Aptamer, DOX Doxorubicin, H&E Hematoxylin and eosin

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