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Table 3 IC50 values of free DOX and nanocarriers on HT-29 and CHO cells during 24, 48, and 72 h of treatments

From: Improving anti-cancer drug delivery performance of magnetic mesoporous silica nanocarriers for more efficient colorectal cancer therapy

Treatments

IC50 (µg/ml) ± SD (HT-29 cells)

IC50 (µg/ml) ± SD (CHO cells)

24 h

48 h

72 h

24 h

48 h

72 h

Free DOX

8.86 ± 1.78

6.83 ± 1.06

4.89 ± 1.06

14.00 ± 1.07

9.63 ± 1.08

5.66 ± 1.06

PEG-Au-NPs@DOX

33.90 ± 1.07

25.38 ± 1.07

15.99 ± 1.05

102.2 ± 1.12

77.01 ± 1.10

54.94 ± 1.26

Apt-PEG-Au-NPs@DOX

9.72 ± 1.08

7.29 ± 1.09

5.52 ± 1.09

320.5 ± 1.24

243.2 ± 1.27

179.2 ± 1.29

  1. SPION Superparamagnetic iron oxide nanoparticle, MSN Mesoporous silica nanoparticle, DOX Doxorubicin, PEG Polyethylene glycol, Apt Aptamer
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Journal of Nanobiotechnology

ISSN: 1477-3155

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