Improving anti-cancer drug delivery performance of magnetic mesoporous silica nanocarriers for more efficient colorectal cancer therapy

Table 4 Examples of theranostic nanocarriers used for therapeutic purposes

Theranostic nanocarriers	Contrast agents	Particle size	Therapeutic agents	Targeting moieties	Cancer cell lines	Animal models	References
YVO4:Eu3 + @MSN	YVO4:Eu3 +	~ 375 nm	DOX	None	HeLa cells	None	[68]
YVO4:Eu3C and Fe ₃O₄-MSN	YVO4:Eu3C	~ 50 nm	DOX	None	HeLa and MCF-7 cells	None	[69]
M-MSN	MnFe₂O₄	~ 100–150 nm	DOX	Folic acid	HeLa cells	Albino mice	[70]
pMMSN	Not used for imaging purpose	175.7 ± 11.4 nm	DOX	None	None	S180 tumor bearing mice	[71]
MMS	Not used for imaging purpose	~ 150 nm	DOX	None	HeLa cells	None	[72]
IONP	IONP	~ 4–10 nm	DOX	Folic acid	HeLa cells	None	[72]
MSN-IONP	IONP	60 ± 2 nm	None	None	LNCaP cells	LNCaP tumor bearing nude mice	[73]
Au@SPIONs	SPION	~ 19 nm	None	MUC-1 aptamer	L929 and HT-29 cells	None	[74]
GoMe	Gold nanoparticle	50.87 ± 10.69 nm	DOX	None	A2058 cells	Lung tumor bearing FVB mice	[75]
SPION	SPION	Not reported	None	Hyaluronic acid	MDA-MB-231 cells	MDA-MB-231 tumor-bearing mice	[76]
Au@MSN	Gold nanoparticle	~ 63.12 nm	5-FU	EpCAM aptamer	HepG2 cells	HepG2 tumor bearing nude mice	[16]
SPION	SPION	~ 58 nm	siRNA	Folic acid	SGC-7901 cells	None	[77]
MMSN	Not used for imaging purpose	18.68 ± 2.31 nm	Epi	None	C26 cells	C26 tumor bearing mice	[78]
SPION	SPION	Below 170 nm	DOX	Folic acid	HCT116 and MCF-7 cells	HCT116 tumor bearing mice	[79]
MSN-EuGd	EuGd	~ 120 nm	None	Hyaluronic acid and TAT peptide	A549 cells	None	[80]
MMSNs	SPION	89.88 ± 4.7 nm	DOX	AS1411 aptamer	MCF-7 cells	None	[59]
SPION@MSN	Not used for imaging purpose	~ 27–50 nm	DOX	MUC-1 aptamer	MCF-7 cells	None	[60]
HMSNsCS-CuS	CuS	150 ± 13 nm	DOX	None	MDA-MB-231 cells	MDA-MB-231 tumor bearing nude mice	[81]

MSN Mesoporous silica nanoparticle, DOX Doxorubicin, M-MSN Mesoporous silica-coated superparamagnetic manganese ferrite (MnFe₂O₄) nanoparticle, pMMSN Phosphonate-terminated magnetic mesoporous nanoparticle, MMS Magnetic mesoporous silica nanoparticle, IONP Iron oxide nanoparticle, MUC-1 Mucin 1, GoMe Gold/Mesoporous silica hybrid nanoparticle, EpCAM Epithelial cell adhesion molecule, MMSN Magnetic mesoporous silica nanoparticle, Epi Epirubicin, HMSNsCS-CuS Mesoporous silica nanoparticles gated by chitosan-copper sulfide composites

ISSN: 1477-3155