Fig. 2From: Simvastatin induced ferroptosis for triple-negative breast cancer therapySchematic illustration of Fe3O4@PCBMA-SIM nanoparticles killing cancer cells (A); The degradation property of Fe3O4@PCBMA nanoparticles dispersed in different concentrations of GSH (0Â mM and 10Â mM) and pH values (5.0, 6.5 and 7.4) (B); Cumulative SIM releasing from Fe3O4-SIM and Fe3O4@PCBMA-SIM nanoparticles dispersed in 10Â mM GSH (C); Cell viability of the MCF-7 (D) and MDA-MB-231 (E) cells after 48Â h incubation with Fe3O4, Fe3O4@PCBMA, SIM, Fe3O4-SIM and Fe3O4@PCBMA-SIM suspensions; CLSM of control, Fe3O4@PCBMA, free SIM, Fe3O4-SIM and Fe3O4@PCBMA-SIM nanoparticles after uptake by MCF-7 and MDA-MB-231 cells (F)Back to article page