Fig. 6
Evaluation of Ti-TCPP MOF in vivo biosafety. a Different concentrations of Ti-TCPP MOF were used in a hemolysis assay. The inset images are of samples following centrifugation after incubation of RBCs with Ti-TCPP MOF (400, 200, 100, 50, or 25 µg mL−1) or water, respectively (n = 3). b Blood urea nitrogen (BUN) levels in healthy mice 14 days post-Ti-TCPP MOF injection (i.v.) (n = 3). c Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, and alkaline phosphatase (ALP) levels in healthy mice at 14 days post-Ti-TCPP MOF injection (i.v.) (n = 3). d H&E-stained images of major organs from healthy control mice 14 days after the i.v. injection of PBS and Ti-TCPP MOF (Scale Bar = 100 µm). Ti-TCPP MOF was injected at a dose of 20 mg/kg