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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: A novel dual-prodrug carried by cyclodextrin inclusion complex for the targeting treatment of colon cancer

Fig. 3

The in vitro cell-growth inhibition effect and cellular uptake of BBA/FA-PEG-CM-β-CD. A Cell growth inhibition rate against CaCo-2 and SW620 cells after incubation with different formulations at 30 μM for 48 h, taking 5-FU as the positive control. Cellular uptake detection through B confocal laser scanning and C the quantitative analysis on the CaCo-2 and SW620 cells. D Competitive inhibition on the cell uptake of BBA/FA-PEG-CM-β-CD by the different concentrations of free folic acid (FA). The mean fluorescence intensity was obtained from the green fluorescence intensity through blue fluorescence correction and analyzed by software Image J. The significance of the differences was evaluated using 2-way ANOVA (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). Data were shown as the mean ± SD in each group (n = 3). Symbols# represented the significant difference between the marked group and the BBA group at the same time (#P < 0.05, ##P < 0.01, ###P < 0.001, ####P < 0.0001)

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