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Table 3 The blood biochemical parameters of serum from mice treated with different formulations

From: A novel dual-prodrug carried by cyclodextrin inclusion complex for the targeting treatment of colon cancer

Groups

ALT (U/L)

BUN (mmol/L)

Cr (μmol/L)

AST (U/L)

Saline

24.2 ± 6.11

8.22 ± 0.97

9.60 ± 3.58

59.5 ± 3.89

FA-PEG-CM-β-CD

19.40 ± 0.82

6.20 ± 1.21

13.57 ± 4.18

59.60 ± 1.01

5-ASA

23.20 ± 2.87

7.82 ± 2.96

9.55 ± 0.36

65.30 ± 1.06

NaB

17.37 ± 1.77

8.60 ± 0.98

8.32 ± 0.98

58.17 ± 4.75

BBA

18.53 ± 0.65

6.32 ± 0.97

8.63 ± 1.96

57.27 ± 10.20

5-FU

292.50 ± 6.60**

6.92 ± 1.20

7.45 ± 2.91

254.00 ± 53.4**

BBA/CM-β-CD

20.77 ± 4.97

6.44 ± 3.60

13.07 ± 1.48

68.17 ± 6.51

BBA/FA-PEG-CM-β-CD

23.87 ± 0.75

7.52 ± 1.57

9.45 ± 1.70

61.87 ± 4.80

  1. Results were presented as mean ± S D (n = 5). Symbols represented statistical significance compared with the saline group
  2. ALT alanine aminotransferase, AST aspartate aminotransferase, Cr creatinine, BUN blood urea nitrogen. **P < 0.01