Table 4 Pharmacokinetic parameters of BBA, BBA/CM-β-CD and BBA/FA-PEG-CM-β-CD in plasma of BALB/C nude mice after oral administration (n = 5)
Parameters | Unit | BBA | BBA/CM-β-CD | BBA/FA-PEG-CM-β-CD |
|---|---|---|---|---|
Cmax | μg/mL | 35.923 ± 0.826 | 28.545 ± 0.716 | 29.445 ± 0.536 |
AUC0-t | μg/mL*h | 219.263 ± 5.360 | 348.252 ± 10.121 | 373.902 ± 4.735 |
MRT0-t | h | 4.769 ± 0.115 | 8.454 ± 0.026 | 8.850 ± 0.065 |
T1/2 | h | 3.396 ± 0.791 | 6.694 ± 1.076 | 8.617 ± 1.422 |
CL | mL/h/kg | 12.760 ± 0.268 | 7.337 ± 0.413 | 6.881 ± 0.699 |