Fig. 13

Effects of AAFC-CDs on frostbite in mice. a Morphology of mouse ear tips: a.1 Model + NS group; a.2 low-dose AAFC-CDs group; a.3 middle-dose AAFC-CDs group; a.4 high-dose AAFC-CDs group. b Histology of HE-stained mice ear tips: b.1 Model + NS group; b.2 low-dose AAFC-CDs group; b.3 middle-dose AAFC-CDs group; b.4 high-dose AAFC-CDs group. c Concentrations of IL-1β. d Concentrations of TNF-αin mouse sera. e Blood glucose levels. *p < 0.05 and **p < 0.01 compared with NS group. *p < 0.05 and **p < .01 compared with control group. Reprinted with permission from ref. [134]. Copyright (2020) The Authors. Published by Informa UK Limited