Fig. 3

DMSN-PEI@125a induce macrophage phenotype switch in vitro. A, B Cytotoxic effect of miR-125a and DMSN-PEI@125a against RAW264.7 cells at different concentrations for A 24 h and B 48 h. C, D TAMs induced from mouse peritoneal macrophages were treated with DMSN-PEI, DMSN-PEI@NC, DMSN-PEI@125a, and miR-125a for 48 h. The mRNA expression levels of C M1 markers (IL-1β, TNF-α) and D M2 markers (Arg-1, TGF-β, Msr-2) in TAMs, and the fold change are normalized to control group (concentration of miR-125a or NC is 200 × 10⁻⁹ M, and DMSN-PEI to miR-125a mass ratio is 20:1)